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5c-APB, also known as 5-(2-aminopropyl)benzofuran, is an empathogenic psychoactive compound belonging to the benzofuran, amphetamine, and phenethylamine classes. It is commonly referred to as “Benzofury” and is available for purchase. Typically sold as the succinate or hydrochloride salt, 5-APB has been circulating as a designer drug since around 2010.

**Pharmacology Of 5c-APB**

5c-APB acts as a serotonin-norepinephrine-dopamine reuptake inhibitor and a serotonin-norepinephrine-dopamine releasing agent. It is a potent agonist for the 5-HT2A and 5-HT2B receptors, with potential cardiotoxic effects observed with long-term use due to its 5-HT2B agonism. Additionally, it acts as an agonist of the 5-HT2C receptor.

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A forensic standard of 5c-APB is available, and the compound is listed on the Forendex website of potential drugs of abuse. The US Department of Justice and DEA have conducted investigations regarding the identification of 5-APB.

**Effects Of 5c-APB**

Users report euphoric effects similar to MDMA but less potent. Recreational use of 5-APB has been associated with fatalities, both in combination with other drugs and as a result of its sole consumption.

**Legitimacy Of 5c-APB**

On June 10, 2014, 5-APB was classified as a class B drug in the UK, along with other benzofuran entactogens and related substances.